1339202-33-3

1339202-33-3 structure

Name: Diazo Biotin-PEG3-azide
Chemical Name: Diazo Biotin-PEG3-Azide
CAS Number: 1339202-33-3
Molecular Formula: C₃₃H₄₅N₉O₇S
Molecular Weight: 711.831
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-10 01:32:08
Modify Date: 2024-01-12 21:58:36
Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Diazo Biotin-PEG3-Azide
Synonyms	1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[13-[4-[(E)-2-[5-(2-azidoethyl)-2-hydroxyphenyl]diazenyl]phenyl]-13-oxo-3,6,9-trioxa-12-azatridec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)- Diazo biotin-azide 4-{(E)-[5-(2-Azidoethyl)-2-hydroxyphenyl]diazenyl}-N-{13-oxo-17-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-3,6,9-trioxa-12-azaheptadec-1-yl}benzamide MFCD28334530 Azo biotin-azide

Description	Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562