1402453-15-9

1402453-15-9 structure

Name: ATIC-IN-1
Chemical Name: L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro-
CAS Number: 1402453-15-9
Molecular Formula: C₂₁H₃₃N₇O₅
Molecular Weight: 463.53062
Catalog: Research Areas Cancer
Create Date: 2018-06-04 09:32:22
Modify Date: 2024-02-08 20:19:30
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

Name	L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro-

Description	ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]
In Vitro	ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制[1]。 ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖[1]。 ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加[1]。 Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 100 μM, 250 μM, 500 μM Incubation Time: 0 h, 24 h, 48 h, and 72 h Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
References	[1]. Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13(11):1628-34.

Molecular Formula	C₂₁H₃₃N₇O₅
Molecular Weight	463.53062