1449390-66-2

1449390-66-2 structure

Name: Cbz-NH-PEG5-CH2COOH
Chemical Name: Z-NH-5(ethylene glycol)-acetic acid
CAS Number: 1449390-66-2
Molecular Formula: C₂₀H₃₁NO₉
Molecular Weight: 429.461
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-05 17:03:55
Modify Date: 2024-01-14 11:51:59
Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Z-NH-5(ethylene glycol)-acetic acid
Synonyms	3-Oxo-1-phenyl-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid 2,7,10,13,16,19-Hexaoxa-4-azaheneicosan-21-oic acid, 3-oxo-1-phenyl-

Description	Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.