1802907-91-0

1802907-91-0 structure

Name: 1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid
Chemical Name: Methyltetrazine-PEG4-Acid
CAS Number: 1802907-91-0
Molecular Formula: C₂₀H₂₈N₄O₇
Molecular Weight: 436.459
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-12 04:33:29
Modify Date: 2024-04-05 15:47:47
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Methyltetrazine-PEG4-Acid
Synonyms	3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]- MFCD28334558 1-[4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy]-3,6,9,12-tetraoxapentadecan-15-oic acid

Description	Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562