1807512-41-9

1807512-41-9 structure

Name: 1,1,1-Trifluoroethyl-PEG4-alcohol
Chemical Name: 1,1,1-Trifluoroethyl-PEG5-Alcohol
CAS Number: 1807512-41-9
Molecular Formula: C₁₀H₁₉F₃O₅
Molecular Weight: 276.250
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-05 23:32:25
Modify Date: 2024-01-09 21:59:09
1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,1,1-Trifluoroethyl-PEG5-Alcohol
Synonyms	3,6,9,12-Tetraoxatetradecan-1-ol, 14,14,14-trifluoro- MFCD28950755 14,14,14-Trifluoro-3,6,9,12-tetraoxatetradecan-1-ol

Description	1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562