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1807518-76-8

1807518-76-8 structure
1807518-76-8 structure
  • Name: Fluorescein-PEG4-Acid
  • Chemical Name: Fluorescein-PEG4-Acid
  • CAS Number: 1807518-76-8
  • Molecular Formula: C32H34N2O11S
  • Molecular Weight: 654.684
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-22 07:32:37
  • Modify Date: 2024-01-09 13:08:34
  • Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Fluorescein-PEG4-Acid
Synonyms MFCD23726637
1-{[3-Carboxy-4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]amino}-1-thioxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oic acid
5,8,11,14-Tetraoxa-2-azaheptadecan-17-oic acid, 1-[[3-carboxy-4-(6-hydroxy-3-oxo-3H-xanthen-9-yl)phenyl]amino]-1-thioxo-
Description Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.5±0.1 g/cm3
Boiling Point 892.9±75.0 °C at 760 mmHg
Molecular Formula C32H34N2O11S
Molecular Weight 654.684
Flash Point 493.8±37.1 °C
Exact Mass 654.188354
LogP 1.16
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.671
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