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1807534-86-6

1807534-86-6 structure
1807534-86-6 structure
  • Name: 3,4-Dibromo-Mal-PEG2-Amine TFA
  • Chemical Name: 3,4-Dibromo-Mal-PEG2-Amine
  • CAS Number: 1807534-86-6
  • Molecular Formula: C10H14Br2N2O4
  • Molecular Weight: 386.037
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-09 15:08:35
  • Modify Date: 2024-01-09 21:58:45
  • 3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 3,4-Dibromo-Mal-PEG2-Amine
Synonyms 1H-Pyrrole-2,5-dione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dibromo-
1-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}-3,4-dibromo-1H-pyrrole-2,5-dione
MFCD27635180
Description 3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.8±0.1 g/cm3
Boiling Point 425.1±45.0 °C at 760 mmHg
Molecular Formula C10H14Br2N2O4
Molecular Weight 386.037
Flash Point 210.9±28.7 °C
Exact Mass 383.932007
LogP -0.21
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.602