189351-79-9

189351-79-9 structure

Name: 19,20-Epoxycytochalasin C
Chemical Name: Epoxycytochalasin C, 19,20-
CAS Number: 189351-79-9
Molecular Formula: C₃₀H₃₇NO₇
Molecular Weight: 523.617
Catalog: Research Areas Cancer
Create Date: 2018-11-25 11:41:42
Modify Date: 2024-01-10 18:49:54
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity[1].

Name	Epoxycytochalasin C, 19,20-
Synonyms	19,20-Epoxycytochalasin C 3H-Oxireno[9,10]cycloundec[1,2-d]isoindole-3,13(4H)-dione, 14-(acetyloxy)-1a,2,5,7a,8,10a,11,12,14,14a-decahydro-2,8-dihydroxy-2,4,9,10-tetramethyl-11-(phenylmethyl)-, (1aR,2R,4S,6E,7aR,8S,10aR,11S,13aR,14aS)- (1aR,2R,4S,6E,7aR,8S,10aR,11S,13aR,14aS)-11-Benzyl-2,8-dihydroxy-2,4,9,10-tetramethyl-3,13-dioxo-2,3,4,5,7a,8,10a,11,12,13,14,14a-dodecahydro-1aH-oxireno[9,10]cycloundeca[1,2-d]isoindol-14-yl acetate

Description	19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
Target	Microbial Metabolite
In Vitro	19,20-Epoxycytochalasin C shows moderate toxicity to cell line SK-MEL with an IC50 of 8.02 µM[1].
In Vivo	Evaluation of in vivo antimalarial activity of 19,20-Epoxycytochalasin C in a mouse model at 100 mg/kg dose shows that this compound has weak suppressive antiplasmodial activity and is toxic to animals[1].
References	[1]. Mallika Kumarihamy, et al. Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf. Molecules. 2019 Feb 21;24(4):777.