201529-58-0

201529-58-0 structure

Name: Salfaprodil
Chemical Name: Salfaprodil
CAS Number: 201529-58-0
Molecular Formula: C₁₈H₁₉NO₃
Molecular Weight: 297.3
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-14 22:38:54
Modify Date: 2026-07-01 15:09:12
(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein.

Name	Salfaprodil

Description	(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein.
Related Catalog	Research Areas >> Neurological Disease
In Vitro	(-)Clausenamide (10 and 100 μM) reverses the overload in [Ca2+]i level stimulated by Aβ25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells[3]. (-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ25-35-treated PC12 cells[3].
References	[1]. Chu S, Liu S, Duan W, et al. The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect. Pharmacol Ther. 2016;162:179-187. [2]. Chu SF, Zhang JT. Recent advances in the study of (-)clausenamide: chemistry, biological activities and mechanism of action. Acta Pharm Sin B. 2014;4(6):417-423. [3]. Hu JF, et al. Protective effect of (-)clausenamide against Abeta-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett. 2010 Oct 8;483(1):78-82.