287194-38-1
287194-38-1 structure
- Name: DHMEQ (racemate)
- Chemical Name: Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide
- CAS Number: 287194-38-1
- Molecular Formula: C13H11NO5
- Molecular Weight: 261.23014
- Catalog: Research Areas Cancer
- Create Date: 2018-07-18 09:39:43
- Modify Date: 2024-01-09 18:51:35
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DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.
| Name | Cis(+/-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzaMide |
|---|---|
| Synonyms | DHMEQ (racemate) |
| Description | DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ. |
|---|---|
| Related Catalog | |
| Target |
NF-κB |
| In Vitro | DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibits TNF-a-induced NF-kB activation. (-)-DHMEQ is more potent and less toxic than DHMEQ racemate[1]. |
| In Vivo | The antiarthritic effects of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) are examined on type-II collagen-induced arthritis in DBA1/J mice. This animal model is widely used for evaluation of antirheumatic drugs because of its pathological similarities to human rheumatoid arthritis. The arthritis is elicited and scored. (-)-DHMEQ markedly inhibits type-II-collagen-induced arthritis in mice, whereas DHMEQ racemate tends to only slightly inhibit it[1]. |
| References |
| Molecular Formula | C13H11NO5 |
|---|---|
| Molecular Weight | 261.23014 |
| Storage condition | 2-8℃ |