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52436-42-7

52436-42-7 structure
52436-42-7 structure
  • Name: Propargyl-PEG1-acrylate
  • Chemical Name: Propargyl-PEG2- acrylate
  • CAS Number: 52436-42-7
  • Molecular Formula: C8H10O3
  • Molecular Weight: 154.163
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-10 19:45:42
  • Modify Date: 2024-01-09 18:57:20
  • Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Propargyl-PEG2- acrylate
Synonyms PROPARGYL-PEG2-AC
Description Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.0±0.1 g/cm3
Boiling Point 214.9±15.0 °C at 760 mmHg
Molecular Formula C8H10O3
Molecular Weight 154.163
Flash Point 81.7±15.0 °C
Exact Mass 154.062988
LogP 1.04
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.451