2098836-50-9

2098836-50-9 structure

Name: AT6
Chemical Name: AT6
CAS Number: 2098836-50-9
Molecular Formula: C₄₈H₅₈ClN₉O₇S₃
Molecular Weight: 1004.68
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2018-08-07 05:53:33
Modify Date: 2024-01-11 18:50:16
AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

Name	AT6

Description	AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.
Related Catalog	Signaling Pathways >> PROTAC >> PROTAC Research Areas >> Cancer
In Vitro	PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells[1].
References	[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.