Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (R)-ADX-47273
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851881-59-9

851881-59-9 structure

851881-59-9 structure

Name: (R)-ADX-47273
Chemical Name: (R)-ADX-47273
CAS Number: 851881-59-9
Molecular Formula: C₂₀H₁₇F₂N₃O₂
Molecular Weight: 369.36
Catalog: Research Areas Neurological Disease
Create Date: 2018-09-30 17:42:44
Modify Date: 2024-01-10 19:38:06
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .

Name	(R)-ADX-47273

Description	(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
Related Catalog	Research Areas >> Neurological Disease
Target	mGluR5:168 nM (EC50)
In Vitro	(R)-ADX-47273 (ADX-47273 (5)) is a potent mGluR5 positive allosteric modulator with an EC50 for potentiation of 168 nM and a 9-fold shift of the glutamate response curve at 1 μM[1].
References	[1]. Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.

Molecular Formula	C₂₀H₁₇F₂N₃O₂
Molecular Weight	369.36

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