1387633-03-5

1387633-03-5 structure

Name: PF-05241328
Chemical Name: PF-05241328
CAS Number: 1387633-03-5
Molecular Formula: C₁₉H₂₁ClN₄O₄S
Molecular Weight: 436.912
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2019-01-20 11:13:33
Modify Date: 2024-01-20 16:23:35
PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.

Name	PF-05241328
Synonyms	1-(5-Chloro-6-isobutoxy-3-pyridinyl)-3-methyl-N-(methylsulfonyl)-1H-indazole-5-carboxamide 1H-Indazole-5-carboxamide, 1-[5-chloro-6-(2-methylpropoxy)-3-pyridinyl]-3-methyl-N-(methylsulfonyl)- PF-05241328

Description	PF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: 31 nM (Nav1.7)[1].
References	[1]. Jones HM, et al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55(7):875-887.