1172846-03-5

1172846-03-5 structure
1172846-03-5 structure

Name Sulfamethoxypyridazine-d3
Synonyms Benzenesulfonamide, 4-amino-N-[6-(methyl-d3-oxy)-3-pyridazinyl]-
4-Amino-N-{6-[(2H3)methyloxy]-3-pyridazinyl}benzenesulfonamide
Description Sulfamethoxypyridazine-d3 is the deuterium-labeled Sulfamethoxypyridazine (HY-B1387)[1]. Sulfamethoxypyridazine (Kynex) a long-acting dulfonamide[2].
Related Catalog
In Vitro 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Boger W P, et al. Sulfamethoxypyridazine (Kynex) a New Long-Acting Sulfonamide[J]. Antibiotic Med., 1956, 3(6): 378-87.

Density 1.5±0.1 g/cm3
Boiling Point 564.9±60.0 °C at 760 mmHg
Molecular Formula C11H9D3N4O3S
Molecular Weight 283.32
Flash Point 295.4±32.9 °C
Exact Mass 283.081848
LogP 0.32
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.647
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
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