897369-18-5
897369-18-5 structure
- Name: BCR-ABL-IN-2
- Chemical Name: BCR-ABL-IN-2
- CAS Number: 897369-18-5
- Molecular Formula: C24H25Cl2N5O3
- Molecular Weight: 502.39
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2019-02-12 06:03:16
- Modify Date: 2024-01-10 16:25:52
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BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively.
| Name | BCR-ABL-IN-2 |
|---|
| Description | BCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. |
|---|---|
| Related Catalog | |
| Target |
ABL1native:57 nM (IC50) ABL1T315I:773 nM (IC50) |
| In Vitro | BCR-ABL-IN-2 (Compound 1) contains a urea moiety to allow a hydrogen bond with the conserved K271-E286 salt bridge of ABL1, a t-butyl moiety to bind into the hydrophobic spine at the third pocket position, and a 2,3-dichlorophenyl ring to stabilize the DFG-phenylalanine F382 in the Type II-out conformation. BCR-ABL-IN-2 exhibits an IC50 of 57 nM for ABL1native and an IC50 of 773 nM for ABL1T315I[1]. Despite ABL, BCR-ABL-IN-2 can also inhibit KDR, BRaf, p38 kinase with IC50s of 1.8 μM, 0.23 μM, 6.3 nM, 43 nM, respectively[2]. |
| References |
| Molecular Formula | C24H25Cl2N5O3 |
|---|---|
| Molecular Weight | 502.39 |