634911-47-0
634911-47-0 structure
- Name: BF-168
- Chemical Name: BF-168
- CAS Number: 634911-47-0
- Molecular Formula: C18H17FN2O2
- Molecular Weight: 312.34
- Catalog: Signaling Pathways Neuronal Signaling Amyloid-β
- Create Date: 2019-02-09 17:53:27
- Modify Date: 2024-01-11 11:29:17
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BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.
| Name | BF-168 |
|---|
| Description | BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42. |
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| Related Catalog | |
| Target |
Ki: 6.4 nM (Aβ1-42)[1]. |
| In Vitro | BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42[1]. |
| In Vivo | Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t1/2=24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [18F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding[1]. |
| References |
| Molecular Formula | C18H17FN2O2 |
|---|---|
| Molecular Weight | 312.34 |