DC Chemicals Limited
China
Product Name: GNE-371
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1926986-36-8

1926986-36-8 structure

1926986-36-8 structure

Name: GNE-371
Chemical Name: GNE-371
CAS Number: 1926986-36-8
Molecular Formula: C₂₄H₂₅N₅O₃
Molecular Weight: 431.49
Catalog: Dye Reagents
Create Date: 2019-02-10 14:03:35
Modify Date: 2024-01-10 11:06:18
GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).

Name	GNE-371

Description	GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Dye Reagents Research Areas >> Others
Target	IC50: 10 nM (TAF1(2))[1].
In Vitro	GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1].
References	[1]. Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61(20):9301-9315.

Molecular Formula	C₂₄H₂₅N₅O₃
Molecular Weight	431.49