1449473-97-5
1449473-97-5 structure
- Name: PF-06305591
- Chemical Name: PF-06305591
- CAS Number: 1449473-97-5
- Molecular Formula: C15H22N4O
- Molecular Weight: 274.36
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2019-03-03 11:55:10
- Modify Date: 2024-03-04 20:34:48
-
PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].
| Name | PF-06305591 |
|---|
| Description | PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 15 nM (NaV1.8)[1]. |
| In Vitro | PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability[1]. |
| In Vivo | PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain[1]. |
| References |
| Molecular Formula | C15H22N4O |
|---|---|
| Molecular Weight | 274.36 |