2133294-96-7

2133294-96-7 structure

Name: Foliglurax monohydrochloride
Chemical Name: Foliglurax monohydrochloride
CAS Number: 2133294-96-7
Molecular Formula: C₂₃H₂₄ClN₃O₃S
Molecular Weight: 457.97
Catalog: Research Areas Neurological Disease
Create Date: 2019-02-13 16:29:14
Modify Date: 2024-01-10 20:07:01
Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].

Name	Foliglurax monohydrochloride

Description	Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant mGluR4 positive allosteric modulator (PAM) with an EC50 of 79±19 nM[1]. Antiparkinsonian effect[1].
Related Catalog	Research Areas >> Neurological Disease
Target	mGlu4:79 nM (EC50)
In Vitro	Foliglurax, a highly selective and potent mGlu4 receptor PAM with a marked brain-penetrance feature, might revolutionize the field of mGlu4 receptor drug targeting in CNS disorders[2].
References	[1]. Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. [2]. Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423.