2089226-94-6
2089226-94-6 structure
- Name: SRPKIN-1
- Chemical Name: SRPK-IN-1
- CAS Number: 2089226-94-6
- Molecular Formula: C27H21FN2O3S
- Molecular Weight: 472.53
- Catalog: Signaling Pathways Cell Cycle/DNA Damage SRPK
- Create Date: 2019-03-03 16:31:01
- Modify Date: 2024-01-10 06:32:36
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SRPK-IN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1].
| Name | SRPK-IN-1 |
|---|
| Description | SRPK-IN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 35.6 nM (SRPK1), 98 nM (SRPK2)[1] |
| In Vitro | SRPK-IN-1 treatment at 200 nM significantly reduces SR protein phosphorylation at the steady state with or without washout[1]. SRPK-IN-1 potently converts VEGF from pro-angiogenic to anti-angiogenic isoform[1]. |
| In Vivo | SRPK-IN-1 blocks angiogenesis in a CNV mouse model through VEGF alternative splicing[1]. |
| References |
| Molecular Formula | C27H21FN2O3S |
|---|---|
| Molecular Weight | 472.53 |