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1848242-58-9

1848242-58-9 structure
1848242-58-9 structure
  • Name: PI3K/mTOR Inhibitor-2
  • Chemical Name: PI3K/mTOR Inhibitor-2
  • CAS Number: 1848242-58-9
  • Molecular Formula: C20H13ClF2N4O4S
  • Molecular Weight: 478.86
  • Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
  • Create Date: 2019-03-03 10:44:04
  • Modify Date: 2024-01-02 18:35:31
  • PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

Name PI3K/mTOR Inhibitor-2
Description PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].
Related Catalog
Target

PI3Kα:3.4 nM (IC50)

PI3Kβ:34 nM (IC50)

PI3Kδ:16 nM (IC50)

PI3Kγ:1 nM (IC50)

mTOR:4.7 nM (IC50)

In Vitro PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively[1].
References

[1]. Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.

Molecular Formula C20H13ClF2N4O4S
Molecular Weight 478.86