2225887-26-1

2225887-26-1 structure
2225887-26-1 structure
  • Name: EGFR-IN-5
  • Chemical Name: EGFR-IN-5
  • CAS Number: 2225887-26-1
  • Molecular Formula: C31H38FN9O
  • Molecular Weight: 571.69
  • Catalog: Signaling Pathways JAK/STAT Signaling EGFR
  • Create Date: 2019-03-30 20:31:34
  • Modify Date: 2024-09-17 11:53:05
  • EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Name EGFR-IN-5
Synonyms MFCD31813637
Description EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.
Related Catalog
Target

EGFR:10.4 nM (IC50)

EGFRL858R:1.1 nM (IC50)

EGFRL858R/T790M:34 nM (IC50)

EGFRL858R/T790M/C797S:7.2 nM (IC50)

References

[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Molecular Formula C31H38FN9O
Molecular Weight 571.69
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