DC Chemicals Limited
China
Product Name: mutant EGFR inhibitor B30
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2225887-26-1

2225887-26-1 structure

2225887-26-1 structure

Name: EGFR-IN-5
Chemical Name: EGFR-IN-5
CAS Number: 2225887-26-1
Molecular Formula: C₃₁H₃₈FN₉O
Molecular Weight: 571.69
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2019-03-30 20:31:34
Modify Date: 2023-01-23 21:55:25
EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Name	EGFR-IN-5
Synonyms	MFCD31813637

Description	EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:10.4 nM (IC50) EGFRL858R:1.1 nM (IC50) EGFRL858R/T790M:34 nM (IC50) EGFRL858R/T790M/C797S:7.2 nM (IC50)
References	[1]. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Molecular Formula	C₃₁H₃₈FN₉O
Molecular Weight	571.69