2057420-29-6

2057420-29-6 structure

Name: Brd9185
Chemical Name: BRD9185
CAS Number: 2057420-29-6
Molecular Formula: C₂₃H₂₁F₆N₃O₂
Molecular Weight: 485.42
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2019-06-01 20:18:57
Modify Date: 2024-01-14 22:02:35
BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].

Name	BRD9185

Description	BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Target	EC50: 16 nM (DHODH in vitro)[1].
References	[1]. Maetani M, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017 Feb 27;8(4):438-442.

Molecular Formula	C₂₃H₂₁F₆N₃O₂
Molecular Weight	485.42