924811-53-0
924811-53-0 structure
- Name: BT18
- Chemical Name: BT18
- CAS Number: 924811-53-0
- Molecular Formula: C30H31F4N3O6S
- Molecular Weight: 637.64
- Catalog: Research Areas Neurological Disease
- Create Date: 2019-06-02 00:20:56
- Modify Date: 2024-01-10 08:15:48
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BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
| Name | BT18 |
|---|
| Description | BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2]. |
|---|---|
| Related Catalog | |
| In Vitro | BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1]. BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1]. BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1]. Western Blot Analysis[1] Cell Line: MG87RET cell lines Concentration: 50 μM Incubation Time: 1, 5, 15, 45, 90 minutes Result: Activated AKT and ERK1/2 in time-dependently. |
| References |
[1]. Leo Jakman, Characterization of small-molecule GDNF mimics. |
| Molecular Formula | C30H31F4N3O6S |
|---|---|
| Molecular Weight | 637.64 |