957471-96-4
957471-96-4 structure
- Name: D13-9001
- Chemical Name: D13-9001
- CAS Number: 957471-96-4
- Molecular Formula: C31H39N11O6S
- Molecular Weight: 693.78
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2019-06-01 15:52:56
- Modify Date: 2024-01-17 17:19:25
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D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].
| Name | D13-9001 |
|---|
| Description | D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2]. |
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| Related Catalog | |
| Target |
KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1] |
| In Vitro | D13-9001 exhibits high solubility and a good safety profile[3]. |
| In Vivo | D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3]. Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3] Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg Administration: Intravenous drip infusion; 2 hours Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone. |
| References |
| Molecular Formula | C31H39N11O6S |
|---|---|
| Molecular Weight | 693.78 |