Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CM 11
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: CM-11
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Homo-PROTAC pVHL30 degrader 1
Price: ￥850.0/100mg ￥1500.0/250mg ￥2900.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2244684-49-7

2244684-49-7 structure

2244684-49-7 structure

Name: CM 11
Chemical Name: Homo-PROTAC pVHL30 degrader 1
CAS Number: 2244684-49-7
Molecular Formula: C₅₈H₈₂N₈O₁₄S₂
Molecular Weight: 1179.45
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2019-06-04 18:06:07
Modify Date: 2025-08-25 18:11:26
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].

Name	Homo-PROTAC pVHL30 degrader 1

Description	Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	pVHL30[1] PROTAC[1]
In Vitro	Homo-PROTAC pVHL30 degrader 1 dimerizes von Hippel-Lindau (VHL) with high avidity in vitro and induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response[1].
References	[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.

Molecular Formula	C₅₈H₈₂N₈O₁₄S₂
Molecular Weight	1179.45
Storage condition	2-8℃

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