387877-45-4

387877-45-4 structure

Name: MBC-11 trisodium
Chemical Name: MBC-11 trisodium salt
CAS Number: 387877-45-4
Molecular Formula: C₁₁H₁₇N₃Na₃O₁₄P₃
Molecular Weight: 577.15
Catalog: Research Areas Cancer
Create Date: 2019-06-04 14:01:27
Modify Date: 2024-01-11 09:16:48
MBC-11 trisodium salt is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD)[1].

Name	MBC-11 trisodium salt

Description	MBC-11 trisodium salt is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10-8 and 10-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10-8 M to 6% at 10-5 M[1] Cell Proliferation Assay[1] Cell Line: Human multiple myeloma cell lines (KAS-6/1, DP-6, KP-6). Concentration: Between 10-8 and 10-4 M. Incubation Time: 48 hours. Result: Significantly inhibited multiple myeloma cell proliferation of each cell line at the majority of the tested concentrations.
In Vivo	MBC-11 (0.04 μg/day, s.c.) has a lower incidence of bone metastases of 40% compared to those treated with PBS (90%) or 0.04 μg/day zoledronate (100%). MBC-11 also significantly decreases bone tumor burden compared to PBS- or zoledronate-treated mice[1]. Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group[1]. These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD)[1]. Animal Model: Approximately four-week old female Balb/c mice inoculated (s.c. injection into their mammary fatpads) with 500,000 4T1/luc cells at day 0 (breast tumor model)[1]. Dosage: 0.04, 0.4, or 4.0 μg/day. Administration: S.C. daily from day 7 to 21. Result: 47% of 17 mice treated with MBC-11 had detectable bone metastases.
References	[1]. Reinholz MM, et al. A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. Bone. 2010 Jul;47(1):12-22.

Molecular Formula	C₁₁H₁₇N₃Na₃O₁₄P₃
Molecular Weight	577.15
Storage condition	2-8℃

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