1638211-04-7

1638211-04-7 structure

Name: ML303
Chemical Name: ML303
CAS Number: 1638211-04-7
Molecular Formula: C₂₁H₁₆F₃N₃O₂
Molecular Weight: 399.37
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2019-06-02 10:39:43
Modify Date: 2024-01-31 10:04:21
ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].

Name	ML303

Description	ML303 is a pyrazolopyridine influenza virus nonstructural protein 1 (NS1) antagonist (IC90 = 155 nM), with an EC50 of 0.7 μM for Influenza A virus H1N1[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
Target	EC50: 0.7 μM (H1N1)[1].
In Vitro	ML303 (20 μM, 6 h) treatment restore IFN-β mRNA levels in MDCK cells[1]. Western Blot Analysis[1] Cell Line: MDCK cells infected with A/PR/8/34, at a MOI of 2, for 6 hours. Concentration: 20 μM. Incubation Time: 6 hours. Result: Restored IFN-β mRNA levels in MDCK cells.
References	[1]. Patnaik S, et al. Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists. Bioorg Med Chem Lett. 2019 May 1;29(9):1113-1119.