2170608-82-7

2170608-82-7 structure

Name: PZ-2891
Chemical Name: PZ-2891
CAS Number: 2170608-82-7
Molecular Formula: C₂₀H₂₃N₅O
Molecular Weight: 349.43
Catalog: Research Areas Neurological Disease
Create Date: 2019-08-07 16:40:16
Modify Date: 2024-01-09 17:08:27
PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA.

Name	PZ-2891

Description	PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 1.3 nM (PANK)[1]
References	[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.