882366-16-7

882366-16-7 structure

Name: SBI-115
Chemical Name: SBI-115
CAS Number: 882366-16-7
Molecular Formula: C₁₄H₁₃ClN₂O₄S
Molecular Weight: 340.78
Catalog: Signaling Pathways GPCR/G Protein GPCR19
Create Date: 2019-06-01 18:50:56
Modify Date: 2024-01-08 19:19:37
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibitingTGR5[1].

Name	SBI-115

Description	SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibitingTGR5[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> GPCR19
In Vitro	SBI-115 (100 and 200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes[1]. Cell Proliferation Assay[1] Cell Line: shRNA-transfected ADPKD cholangiocytes Concentration: 100 and 200 µM Incubation Time: 24 hours Result: Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA.
References	[1]. Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218.