2222354-61-0

2222354-61-0 structure

2222354-61-0 structure

Name: SNIPER(ABL)-058
Chemical Name: SNIPER(ABL)-058
CAS Number: 2222354-61-0
Molecular Formula: C₆₂H₇₅N₁₁O₉S
Molecular Weight: 1150.39
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
Create Date: 2019-06-01 21:10:17
Modify Date: 2024-01-11 12:05:08
SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

Name	SNIPER(ABL)-058

Description	SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Molecular Formula	C₆₂H₇₅N₁₁O₉S
Molecular Weight	1150.39