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1326852-06-5

1326852-06-5 structure
1326852-06-5 structure
  • Name: Compound L
  • Chemical Name: STL127705
  • CAS Number: 1326852-06-5
  • Molecular Formula: C22H20FN5O4
  • Molecular Weight: 437.42
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA-PK
  • Create Date: 2019-06-01 19:09:10
  • Modify Date: 2024-01-12 08:43:33
  • STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

Name STL127705
Description STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].
Related Catalog
Target

IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]

References

[1]. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.

Molecular Formula C22H20FN5O4
Molecular Weight 437.42