1361563-03-2
1361563-03-2 structure
- Name: Aldoxorubicin•HCl
- Chemical Name: Aldoxorubicin hydrochloride
- CAS Number: 1361563-03-2
- Molecular Formula: C37H43ClN4O13
- Molecular Weight: 787.21
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
- Create Date: 2019-06-16 15:21:31
- Modify Date: 2025-08-26 08:20:54
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Aldoxorubicin (INNO-206) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin hydrochloride (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.
| Name | Aldoxorubicin hydrochloride |
|---|---|
| Synonyms |
S098K6HGD9
Aldoxorubicin hydrochloride N'-[(1E)-1-{(2S,4S)-4-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl}-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro -1H-pyrrol-1-yl)hexanehydrazide hydrochloride (1:1) 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2-[(1E)-1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphth acenyl]-2-hydroxyethylidene]hydrazide, hydrochloride (1:1) MFCD25371995 |
| Description | Aldoxorubicin (INNO-206) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin hydrochloride (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase II[4] |
| In Vitro | Aldoxorubicin hydrochloride (INNO-206)? (0.27 to 2.16 μM) inhibits blood vessel formation and reduces multiple myeloma cell growth in a pH-dependent fashion[1]. |
| In Vivo | Aldoxorubicin hydrochloride (INNO-206) (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1]. Aldoxorubicin hydrochloride (INNO-206) shows a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study[2]. Aldoxorubicin hydrochloride (INNO-206) shows superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models[3]. |
| References |
| Molecular Formula | C37H43ClN4O13 |
|---|---|
| Molecular Weight | 787.21 |
| Exact Mass | 786.251526 |
| Appearance | Powder |
| Storage condition | store at -20℃ for one year（Powder） |