669770-29-0

669770-29-0 structure

Name: AQW-051
Chemical Name: AQW051
CAS Number: 669770-29-0
Molecular Formula: C₁₉H₂₂N₂O
Molecular Weight: 294.391
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2019-06-16 17:21:58
Modify Date: 2024-01-16 19:20:33
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety[1].

Name	AQW051
Synonyms	JQH481R778 1-Azabicyclo[2.2.2]octane, 3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-, (3R)- MFCD28502153 AQW051 (3R)-3-{[6-(4-Methylphenyl)-3-pyridinyl]oxy}quinuclidine

Description	VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	VQW-765 对重组表达的人 α7-nACh 受体的 pKD 值为 7.56[1]。 VQW-765 在 GH3-ha7-22 细胞中重组表达的人 α7-nACh 受体刺激后，显示出对钙瞬态的强大激动活性，pEC50 值为 7.41[1]。
In Vivo	VQW-765 (0.03 和 0.3 mg/kg；口服，一次) 增加小鼠的认知和学习、记忆表现[1]。 VQW-765 (1 mg/kg；口服，一次) 显示出抗焦虑作用，增加大鼠的社会探索时间，持续时间至少6小时[1]。 Animal Model: OF1/IC strain adult mice[1] Dosage: 0.03 and 0.3 mg/kg Administration: Oral administration; 0.03 and 0.3 mg/kg once Result: Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).
References	[1]. Feuerbach D, et al. AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation. Br J Pharmacol. 2015 Mar;172(5):1292-304.

Density	1.2±0.1 g/cm3
Boiling Point	443.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₂N₂O
Molecular Weight	294.391
Flash Point	222.2±28.7 °C
Exact Mass	294.173218
LogP	3.69
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.622
Storage condition	store at -20℃ for one year（Powder）

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