Top Suppliers:I want be here


1642333-05-8

1642333-05-8 structure
1642333-05-8 structure
  • Name: 22-(tert-Butoxy)-22-oxodocosanoic acid
  • Chemical Name: 22-(tert-Butoxy)-22-oxodocosanoic acid
  • CAS Number: 1642333-05-8
  • Molecular Formula: C26H50O4
  • Molecular Weight: 426.673
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2019-08-04 00:32:58
  • Modify Date: 2024-01-01 20:52:59
  • 22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t

Name 22-(tert-Butoxy)-22-oxodocosanoic acid
Synonyms 22-[(2-Methyl-2-propanyl)oxy]-22-oxodocosanoic acid
Docosanedioic acid, mono(1,1-dimethylethyl) ester
Description 22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula C26H50O4
Molecular Weight 426.673
Exact Mass 426.370911