Name | 22-(tert-Butoxy)-22-oxodocosanoic acid |
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Synonyms |
22-[(2-Methyl-2-propanyl)oxy]-22-oxodocosanoic acid
Docosanedioic acid, mono(1,1-dimethylethyl) ester |
Description | 22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t |
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Related Catalog | |
Target |
Non-cleavable |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
References |
Molecular Formula | C26H50O4 |
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Molecular Weight | 426.673 |
Exact Mass | 426.370911 |