1402055-25-7

1402055-25-7 structure
1402055-25-7 structure
  • Name: Cdc7-IN-1
  • Chemical Name: Cdc7-IN-1
  • CAS Number: 1402055-25-7
  • Molecular Formula: C21H16ClN3O4
  • Molecular Weight: 409.82
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2019-08-04 13:28:59
  • Modify Date: 2024-01-16 10:07:17
  • Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].

Name Cdc7-IN-1
Description Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1].
Related Catalog
Target

IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1]

References

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.

Molecular Formula C21H16ClN3O4
Molecular Weight 409.82