1477497-01-0

1477497-01-0 structure

Name: UDM-001651
Chemical Name: UDM-001651
CAS Number: 1477497-01-0
Molecular Formula: C₂₈H₂₃N₃O₅S
Molecular Weight: 513.56
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2019-08-04 11:14:58
Modify Date: 2024-01-03 07:07:14
UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1].

Name	UDM-001651

Description	UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 shows antiplatelet potency (IC50=25 nM) in a γ-thrombin-induced platelet-rich plasma aggregation assay (γ-Thr PRP)[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
Target	IC50: 4 nM (PAR4)[1] Kd: 1.4 nM (PAR4)[1]
References	[1]. Miller MM, et al. Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy. J Med Chem. 2019 Jun 27.

Molecular Formula	C₂₈H₂₃N₃O₅S
Molecular Weight	513.56