2092923-21-0

2092923-21-0 structure

Name: VU 6008667
Chemical Name: VU 6008667
CAS Number: 2092923-21-0
Molecular Formula: C₂₄H₁₇ClF₂N₂O₂
Molecular Weight: 438.85
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2019-08-03 17:52:58
Modify Date: 2024-01-14 13:27:32
VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].

Name	VU 6008667

Description	VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. VU 6008667 has high CNS penetration[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Molecular Formula	C₂₄H₁₇ClF₂N₂O₂
Molecular Weight	438.85