909387-87-7

909387-87-7 structure

Name: DL001
Chemical Name: DL001
CAS Number: 909387-87-7
Molecular Formula: C₄₉H₇₅NO₁₂
Molecular Weight: 870.12
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2019-09-07 11:56:18
Modify Date: 2024-01-09 19:26:45
DL001, a FKBP12-dependent rapamycin analog, is a selective mechanistic Target Of Rapamycin Complex 1 (mTORC1) inhibitor with an IC50 of 74.9 pM. In cells, DL001 efficiently represses elevated mTORC1 activity and restores normal gene expression to cells lacking a functional tuberous sclerosis complex. DL001 inhibits mTORC1 signaling without impairing glucose homeostasis and with substantially reduced and no side effects on lipid metabolism and the immune system in vivo in C57BL/6J mice[1].

Name	DL001

Description	DL001, a FKBP12-dependent rapamycin analog, is a selective mechanistic Target Of Rapamycin Complex 1 (mTORC1) inhibitor with an IC50 of 74.9 pM. In cells, DL001 efficiently represses elevated mTORC1 activity and restores normal gene expression to cells lacking a functional tuberous sclerosis complex. DL001 inhibits mTORC1 signaling without impairing glucose homeostasis and with substantially reduced and no side effects on lipid metabolism and the immune system in vivo in C57BL/6J mice[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Others
Target	mTORC1:74.9 pM (IC50)
References	[1]. Schreiber KH , et al. A novel rapamycin analog is highly selective for mTORC1 in vivo. Nat Commun. 2019 Jul 19;10(1):3194.

Molecular Formula	C₄₉H₇₅NO₁₂
Molecular Weight	870.12