1808714-73-9

1808714-73-9 structure

Name: EN6
Chemical Name: EN6
CAS Number: 1808714-73-9
Molecular Formula: C₁₉H₁₄F₂N₄O₂
Molecular Weight: 368.34
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2019-09-09 10:53:51
Modify Date: 2024-01-10 22:17:50
EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].

Name	EN6

Description	EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase). EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner[1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
References	[1]. Chung CY, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019 Aug;15(8):776-785.

Molecular Formula	C₁₉H₁₄F₂N₄O₂
Molecular Weight	368.34