1423077-49-9
1423077-49-9 structure
- Name: RTC-5
- Chemical Name: RTC-5
- CAS Number: 1423077-49-9
- Molecular Formula: C24H22ClF3N2O3S
- Molecular Weight: 510.96
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2019-09-07 19:46:16
- Modify Date: 2024-01-05 16:14:13
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RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1].
| Name | RTC-5 |
|---|
| Description | RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: EGFR[1] |
| In Vitro | RTC-5 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 12.6μM[1]. RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression[1]. Cell Viability Assay[1] Cell Line: H1650 lung adenocarcinoma cells Concentration: 0 μM, 1 μM, 10 μM, 20 μM, 30 μM, 40 μM Incubation Time: 48 hours Result: Inhibited H1650 lung adenocarcinoma cell growth. Western Blot Analysis[1] Cell Line: H1650 lung adenocarcinoma cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours Result: Decreased p-AKT, p-ERK expression. |
| References |
| Molecular Formula | C24H22ClF3N2O3S |
|---|---|
| Molecular Weight | 510.96 |