2133017-36-2
2133017-36-2 structure
- Name: GLP-26
- Chemical Name: GLP-26
- CAS Number: 2133017-36-2
- Molecular Formula: C19H17F2N3O3
- Molecular Weight: 373.35
- Catalog: Signaling Pathways Anti-infection HBV
- Create Date: 2019-10-09 10:13:29
- Modify Date: 2024-01-09 18:35:32
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GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].
| Name | GLP-26 |
|---|
| Description | GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1]. |
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| Related Catalog | |
| In Vitro | GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells Concentration: 0.7-1.7 μM Incubation Time: 3 days Result: Reduced secreted HBeAg in HepNTCP-DL cells. |
| References |
| Molecular Formula | C19H17F2N3O3 |
|---|---|
| Molecular Weight | 373.35 |