2133017-36-2

2133017-36-2 structure

Name: GLP-26
Chemical Name: GLP-26
CAS Number: 2133017-36-2
Molecular Formula: C₁₉H₁₇F₂N₃O₃
Molecular Weight: 373.35
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2019-10-09 10:13:29
Modify Date: 2024-01-09 18:35:32
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].

Name	GLP-26

Description	GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells Concentration: 0.7-1.7 μM Incubation Time: 3 days Result: Reduced secreted HBeAg in HepNTCP-DL cells.
References	[1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.

Molecular Formula	C₁₉H₁₇F₂N₃O₃
Molecular Weight	373.35