2092917-63-8

2092917-63-8 structure

Name: (Rac)-VU 6008667
Chemical Name: Rac-VU 6008667
CAS Number: 2092917-63-8
Molecular Formula: C₂₄H₁₇ClF₂N₂O₂
Molecular Weight: 438.85
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2019-10-08 19:35:29
Modify Date: 2024-01-09 20:29:40
Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration[1].

Name	Rac-VU 6008667

Description	Rac-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. Rac-VU 6008667 has high CNS penetration[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	IC50: 1.2 μM (Human M5); 1.6 μM (Rat M5)[1]
References	[1]. McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

Molecular Formula	C₂₄H₁₇ClF₂N₂O₂
Molecular Weight	438.85