1226549-49-0

1226549-49-0 structure

Name: DBPR112
Chemical Name: DBPR112
CAS Number: 1226549-49-0
Molecular Formula: C₃₂H₃₁N₅O₃
Molecular Weight: 533.62
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2019-12-08 21:20:19
Modify Date: 2024-01-16 18:03:59
DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy[1].

Name	DBPR112

Description	DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFRWT:15 nM (IC50) EGFRL858R/T790M:48 nM (IC50)
References	[1]. Lin SY, et al. Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. J Med Chem. 2019 Sep 27.

Molecular Formula	C₃₂H₃₁N₅O₃
Molecular Weight	533.62