2366269-23-8

2366269-23-8 structure

Name: Palbociclib-propargyl
Chemical Name: Palbociclib-propargyl
CAS Number: 2366269-23-8
Molecular Formula: C₂₇H₃₁N₇O₂
Molecular Weight: 485.58
Catalog: Research Areas Cancer
Create Date: 2019-12-07 11:14:37
Modify Date: 2024-01-15 18:07:41
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].

Name	Palbociclib-propargyl

Description	Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.