1414842-70-8

1414842-70-8 structure

Name: VU0364770 hydrochloride
Chemical Name: VU0364770 hydrochloride
CAS Number: 1414842-70-8
Molecular Formula: C₁₂H₁₀Cl₂N₂O
Molecular Weight: 269.13
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-12-08 16:06:19
Modify Date: 2024-01-10 18:43:02
VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].

Name	VU0364770 hydrochloride

Description	VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR
Target	Rat mGlu4:290 nM (EC50) Human mGlu4:1.1 μM (EC50) mGlu6:6.8 μM (EC50) mGlu5:17.9 μM (EC50)
References	[1]. Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

Molecular Formula	C₁₂H₁₀Cl₂N₂O
Molecular Weight	269.13