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2376328-55-9

2376328-55-9 structure
2376328-55-9 structure
  • Name: K-Ras G12C-IN-4
  • Chemical Name: K-Ras G12C-IN-4
  • CAS Number: 2376328-55-9
  • Molecular Formula: C31H33ClN4O4
  • Molecular Weight: 561.07
  • Catalog: Signaling Pathways GPCR/G Protein Ras
  • Create Date: 2019-12-08 18:48:19
  • Modify Date: 2024-01-15 11:55:37
  • K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].
Name K-Ras G12C-IN-4
Description K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].
Related Catalog
In Vitro K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1]. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].
References

[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.
Molecular Formula C31H33ClN4O4
Molecular Weight 561.07

Chemsrc provides CAS#:2376328-55-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2376328-55-9 | Chemsrc address: https://m.chemsrc.com/en/baike/1559522.html

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