1035638-91-5

1035638-91-5 structure
1035638-91-5 structure
  • Name: PF 6274484
  • Chemical Name: PF-6274484
  • CAS Number: 1035638-91-5
  • Molecular Formula: C18H14ClFN4O2
  • Molecular Weight: 372.781
  • Catalog: Signaling Pathways JAK/STAT Signaling EGFR
  • Create Date: 2020-01-12 20:33:50
  • Modify Date: 2024-04-03 07:24:36
  • PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).

Name PF-6274484
Synonyms PF-6274484
MFCD30182370
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}acrylamide
Description PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).
In Vitro PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).
Density 1.4±0.1 g/cm3
Boiling Point 578.3±50.0 °C at 760 mmHg
Molecular Formula C18H14ClFN4O2
Molecular Weight 372.781
Flash Point 303.5±30.1 °C
Exact Mass 372.078918
LogP 3.87
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.691
Storage condition -20°C