1090893-12-1
1090893-12-1 structure
- Name: Z62954982
- Chemical Name: 3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide
- CAS Number: 1090893-12-1
- Molecular Formula: C20H21N3O5S
- Molecular Weight: 415.463
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2020-01-11 17:51:50
- Modify Date: 2024-01-18 20:27:32
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Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC.
| Name | 3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide |
|---|---|
| Synonyms |
3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide
Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]- |
| Description | Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC. |
|---|---|
| References | References 1. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490. 2. Lobastova L, et al. Cell Oncol (Dordr). 2017 Feb;40(1):63-76. 3. Yamaguchi N, et al. Sci Rep. 2015 Jan 7;5:7656. 4. Ferri N, et al. J Med Chem. 2009 Jul 23;52(14):4087-90. View Related Products by Target Small GTPase |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H21N3O5S |
| Molecular Weight | 415.463 |
| Exact Mass | 415.120178 |
| LogP | 1.49 |
| Index of Refraction | 1.618 |