1090893-12-1

1090893-12-1 structure

Name: Z62954982
Chemical Name: 3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide
CAS Number: 1090893-12-1
Molecular Formula: C₂₀H₂₁N₃O₅S
Molecular Weight: 415.463
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2020-01-11 17:51:50
Modify Date: 2024-01-18 20:27:32
Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC.

Name	3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide
Synonyms	3-[(3,5-Dimethyl-1,2-oxazol-4-yl)methoxy]-N-(4-methyl-3-sulfamoylphenyl)benzamide Benzamide, N-[3-(aminosulfonyl)-4-methylphenyl]-3-[(3,5-dimethyl-4-isoxazolyl)methoxy]-

Description	Z62954982 is a potent, specific Rac1 inhibitor, reduces the intracellular levels of Rac1-GTP in a concentration-dependent manner with IC50 of 12 uM, 4 times more effective than NSC23766 (IC50=50 uM); causes a concentration-dependent decrease in transendothelial electrical resistance (TER) in both HDMEC and HUVEC.
References	References 1. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490. 2. Lobastova L, et al. Cell Oncol (Dordr). 2017 Feb;40(1):63-76. 3. Yamaguchi N, et al. Sci Rep. 2015 Jan 7;5:7656. 4. Ferri N, et al. J Med Chem. 2009 Jul 23;52(14):4087-90. View Related Products by Target Small GTPase